PAIN-FREE · SMART DELIVERY
NEO
SHOT
Gentle delivery, engineered.
An ultra-fine spicule that removes the sting and raises delivery. Every GIPPEUN formula is built on this one technology.
LONGEVITY FORMULA
PDRN
+ NAD
Recovery, meets energy.
PDRN for recovery, NAD⁺ for energy — a longevity formula built on top of the delivery technology.
TEST RESULTS
Clinical
results
Proven by testing.
Human application and in-vitro study data from HUMAN Skin Clinical Trial Center. The difference, in numbers.
01 — WHAT IS A SPICULE?
To carry good ingredients in,
the spicule arrived.
A spicule is a micro-needle structure. It opens pathways through which actives travel — a high-efficiency delivery technology.
02 — THE FIRST GENERATION
It worked. But it was
too harsh for every day.
First-generation spicules were large and rough, leaving redness and stinging behind. Sensitive skin could barely use them, and the burden grew with repetition. They delivered — but they were never a technology you could live with daily.
Stinging
“It stung so much when I applied it that my eyes watered. It felt like needles in my face.”
Itching
“The irritation kept building and it itched so badly I was scratching my face at 3 a.m.”
Redness
“Far too harsh. My face went red and it took forever to calm down.”
Not for sensitive skin
“One use and my skin has been reactive for a month. The irritation disrupted my daily life.”
Source: quoted from user reviews of first-generation spicule products
Reference footage: first-generation spicule structure
So we asked again
“Can we cut the irritation
without losing the delivery?”
03 — HOW 1 · SHRINK IT
Make the spicule small and precise —
and the sting disappears.
From 220µm down to 60µm — more than three times smaller.
1st-gen spicule
NEO SHOT
Actual microscopy images.
04 — HOW 2 · WIDEN THE SPACE
Smaller — yet it carries
up to 23× more.
The empty space inside a spicule — its porosity — is where actives sit. We shrank the structure and widened that space, fitting more into the same volume.
Porosity · space for actives
- · Long, rough structure
- · Narrow porosity · low payload
- · Irritation and redness
- · Animal-derived
Porosity 3% → 70%
More actives carried
Porosity · space for actives
- · Ultra-fine structure
- · Wide porosity · high payload
- · Gentle · comfortable
- · Vegan
Conceptual cross-section of spicule porosity · based on SEM imaging
05 — 10 MILLION SHOTS
We packed the smaller NEO SHOT with PDRN and NAD⁺ — 10 million shots in a single bottle.
Based on Skin Boost Serum
06 — SEE IT MOVE
See the difference
for yourself.
First-generation spicules are large enough to irritate the skin.
NEO SHOT is small enough to score an irritation index of 0.00.
Experience PDRN and NAD⁺, loaded into every NEO SHOT.
About this ingredient information
The PDRN and NAD⁺ content in this tab describes the general properties of these ingredients and the research around them, and is provided for information only. It does not represent a claim about the efficacy of GIPPEUN products.
LONGEVITY FORMULA
Into NEO SHOT we loaded PDRN for recovery and NAD⁺ for energy.
A good ingredient cannot sustain change if it never reaches the skin. Into NEO SHOT, GIPPEUN loaded PDRN, known to support recovery from damage, and NAD⁺, tied to cellular energy — so that what is delivered can actually work.
PDRN · NEO SHOT
The repair half — focused on refilling compromised skin.
NAD · NEO SHOT
The condition half — focused on waking skin energy.
The PDRN 6 : NAD⁺ 4 balance is how GIPPEUN designed recovery and energy to work together — the architecture of our longevity formula.
02 — PDRN · THE INGREDIENT
PDRN, the core of recovery —
with the depth of ginseng.
K-GINSENG PDRN.
PDRN is a next-generation skin repair ingredient long noted in aesthetic practice, and is known to support the improvement of a compromised skin environment and the activation of renewal. GIPPEUN adds the depth of Korean ginseng to it, pursuing synergy between recovery and firmness.
Comparative characteristics of K-Ginseng-derived PDRN at the raw-material level. These figures do not represent the efficacy of any individual product. The chart is a schematic and may not reflect exact proportions.
03 — NAD⁺ · THE INGREDIENT
The cellular energy molecule
tied to how fast skin ages: NAD⁺.
NAD⁺ has drawn attention from Harvard researchers and the wider bio-beauty field. Differences in how fast skin ages are understood to begin with differences in cellular energy, and NAD⁺ — which declines with age — sits at the centre of that conversation.
NAD⁺ by age · declining after the 30s (conceptual)
A conceptual illustration of how NAD⁺ generally declines. Individual variation applies; it does not represent product efficacy.
04 — NEO SHOT LINE-UP
The GIPPEUN NEO SHOT line, built on this formula.
NEO SHOT · SERUM
GIPPEUN NEO SHOT
Skin Boost Serum
NEO SHOT · CREAM
GIPPEUN NEO SHOT
Longrun Cream
The PDRN and NAD⁺ content on this page is provided as ingredient and general health information. It is not intended to diagnose, treat, cure or prevent any disease.
TEST RESULTS — THE EVIDENCE
No irritation — and it still delivers.
To verify "less irritation without losing delivery," GIPPEUN ran a series of studies on both the serum and the cream at HUMAN Skin Clinical Trial Center. Here are the results, one by one.
01 — FIRST, NO STING
Unlike first-generation spicules: irritation index 0.00.
First-generation spicules left stinging and redness alongside their results. NEO SHOT was different. In a patch test on 33 highly sensitive panelists, both the serum and the cream scored an irritation index of 0.00 — non-irritating, the highest grade.
Sensitivity: primary irritation patch study on 33 highly sensitive panelists — non-irritating (Excellent, highest grade). Ocular: in-vitro reconstructed human cornea model (MCTT HCE™) — non-irritant. Conducted by HUMAN Skin Clinical Trial Center.
02 — AND STILL, IT DELIVERS
Gentler — and delivery is actually better.
Gentle means nothing if the actives never sink in. So we measured absorption directly. Compared with the same serum without NEO SPICULES, actives were carried in greater quantity (+66.8%) and far deeper (12.23 → 39.68µm).
HUMAN Skin Clinical Trial Center · 20 subjects · after a single use · comparison of absorption quantity, depth and rate, with vs. without NEO SPICULES.
03 — WHAT ARRIVES, WORKS
What is delivered actually goes to work.
What is delivered has to do something once it arrives. In cell studies, the GIPPEUN core actives showed collagen expression at 137.4% and hyaluronic acid at 140.6% against a negative control.
HUMAN Skin Clinical Trial Center · in-vitro (cell) study on human dermal fibroblasts (HDFa) · expression against a negative control (collagen 137.4% · hyaluronic acid 140.6%).
04 — AND IT SHOWS
Texture, firmness, pores — change you can see.
Change that begins inside eventually shows on the surface. After a single use, we measured three groups of outcomes separately. User satisfaction was 100% across every item.
HUMAN Skin Clinical Trial Center · 22 subjects · after a single use · human application studies on seven pore measures, 3D volume firmness and three density measures · zero adverse events. For pore and roughness items, a decrease indicates improvement.
GIPPEUN, backed by clinical testing.
Try it now.
Collagen, hyaluronic acid and ocular irritation figures come from in-vitro (cell / tissue model) studies; all other figures come from human application studies. Results may vary by individual and do not guarantee any specific outcome.
